Effects of bicarbonate/lactate-buffered neutral peritoneal dialysis fluids on angiogenesis-related proteins in patients undergoing peritoneal dialysis

Abstract Background In order to facilitate the safe and long-term delivery of peritoneal dialysis (PD), it is necessary improve biocompatibility fluids (PDFs). The novel bicarbonate/lactate-buffered neutral PDFs (B/L-PDFs) are expected be improved biocompatible. This study evaluated B/L-PDFs by analysis on profile angiogenesis-related proteins in drained dialysate patients undergoing PD. Methods Concentrations 20 were semi-quantitatively determined using a RayBio® Human Angiogenesis Antibody Array compared between conventional lactate-buffered (L-PDFs). Results expression growth-related oncogene (GRO α/β/γ), which belongs CXC chemokine family, decreased significantly after use L-PDFs ( P = 0.03). number with lower level was negatively correlated PD duration (Spearman ρ − 0.81, 0.004). Conclusion suggested that more biocompatible than PDFs.